Pain Relief from Ximenia americana Bark Extract and Caffeic Acid
Author Information
Author(s): Renata Torres Pessoa, Lucas Yure Santos da Silva, Isabel Sousa Alcântara, Tarcísio Mendes Silva, Eduardo dos Santos Silva, Roger Henrique Sousa da Costa, Aparecida Barros da Silva, Jaime Ribeiro-Filho, Anita Oliveira Brito Pereira Bezerra Martins, Henrique Douglas Melo Coutinho, Jean Carlos Pereira Sousa, Andréa Rodrigues Chaves, Ricardo Neves Marreto, Irwin Rose Alencar de Menezes
Primary Institution: Regional University of Cariri (URCA)
Hypothesis
This study aimed to investigate the antinociceptive effect of Ximenia americana L. bark extract and its main component, caffeic acid, in animal models.
Conclusion
Ximenia americana bark extract and caffeic acid show significant pain-relieving effects by modulating various pain pathways.
Supporting Evidence
- HEXA significantly increased latency in the hot plate test.
- HEXA reduced abdominal writhing by up to 89.49%.
- Caffeic acid reduced licking time in the formalin test.
- HEXA modulated multiple pain signaling pathways.
- HEXA did not alter motor coordination in the rotarod test.
Takeaway
The bark of a plant called Ximenia americana and a chemical in it, caffeic acid, can help reduce pain in mice.
Methodology
The study used in vivo assays including abdominal writhing, hot plate, and Von Frey tests to assess antinociceptive properties.
Limitations
The molecular targets of HEXA and CA remain to be fully investigated.
Participant Demographics
Swiss mice of both sexes weighing 20–30 g.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website