Amylin and Metabolic Syndrome in Healthy Chinese Adults
Author Information
Author(s): Hou Xinwei, Sun Liang, Li Zongmeng, Mou Haiwei, Yu Zhijie, Li Huaixing, Jiang Peizhen, Yu Danxia, Wu Hongyu, Ye Xingwang, Lin Xu, Le Yingying
Primary Institution: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Hypothesis
The study aimed to evaluate the distribution of circulating amylin and its association with metabolic syndrome (MetS) in apparently healthy Chinese adults.
Conclusion
The study suggests that amylin is strongly associated with inflammatory markers and metabolic syndrome, independent of established risk factors.
Supporting Evidence
- Plasma amylin concentrations were higher in overweight/obese participants than normal-weight counterparts.
- Circulating amylin was positively associated with inflammatory markers like CRP and IL-6.
- The risk of metabolic syndrome was significantly higher in the highest amylin quartile.
- The association of amylin with metabolic syndrome remained significant after controlling for BMI and insulin resistance.
Takeaway
This study found that higher levels of a hormone called amylin are linked to a higher risk of metabolic problems in healthy adults, even if they are not overweight.
Methodology
A population-based sample of 1,011 Chinese adults aged 35–54 years was studied to measure plasma amylin and various metabolic parameters.
Limitations
The cross-sectional nature of the study limits the ability to establish causation between amylin levels and metabolic syndrome.
Participant Demographics
Participants were Chinese men and women aged 35–54 years.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 2.53 to 5.46
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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