Diet and Body Constitution in Relation to Breast Cancer Subgroups
Author Information
Author(s): Borgquist Signe, Wirfält Elisabet, Jirström Karin, Anagnostaki Lola, Gullberg Bo, Berglund Göran, Manjer Jonas, Landberg Göran
Primary Institution: Malmö University Hospital
Hypothesis
Is there an association between diet, body constitution, and different subgroups of breast cancer defined by tumor grade and proliferation?
Conclusion
Low energy and low total fat intakes, particularly of polyunsaturated fatty acids, and high body mass index are associated with more malignant breast tumors.
Supporting Evidence
- A large hip circumference and high body mass index were associated with high grade tumors.
- Low energy and unadjusted fat intakes were associated with high proliferation.
- Low intakes of saturated, monounsaturated, and polyunsaturated fatty acids were associated with high proliferation.
Takeaway
Eating less energy and fat, especially certain types of fat, and being heavier might mean a higher chance of having more serious breast cancer.
Methodology
The study analyzed dietary and body measurements of 346 women diagnosed with breast cancer, comparing them with tumor characteristics using analysis of variance.
Potential Biases
Potential measurement errors in dietary assessments could bias the results.
Limitations
The study did not include healthy control individuals, which may limit the generalizability of the findings.
Participant Demographics
Participants were women aged between 1923 and 1950, with a total of 17,035 women enrolled in the Malmö Diet and Cancer study.
Statistical Information
P-Value
0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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