Host–Pathogen Interactions: A Biological Rendez-Vous of the Infectious Nonself and Danger Models?
2006
Host-Pathogen Interactions: Understanding Immune Responses
publication
Author Information
Author(s): Jean-Nicolas Tournier, Anne Quesnel-Hellmann
Primary Institution: Centre de Recherches du Service de Santé des Armées, Grenoble, France
Hypothesis
How do pathogens manipulate host immune responses through various mechanisms?
Conclusion
Pathogens have evolved strategies to interfere with host immune responses, leading to tolerance and evasion of immune detection.
Supporting Evidence
- Pathogens use strategies that impair pattern recognition receptors and danger receptors.
- Viruses and bacteria have developed various methods to disrupt immune signaling pathways.
- Apoptosis of antigen-presenting cells can be induced by pathogens to suppress immune responses.
Takeaway
Pathogens can trick our body's defenses by using special tricks to hide from the immune system, making it harder for us to fight infections.
Digital Object Identifier (DOI)
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