Plasminogen activator inhibitor 1 may promote tumour growth through inhibition of apoptosis
2000
How Plasminogen Activator Inhibitor 1 Affects Tumor Growth
publication
Author Information
Author(s): Kwaan H C, Wang J, Svoboda K, Declerck P J
Primary Institution: Northwestern University Medical School
Hypothesis
Does Plasminogen activator inhibitor 1 (PAI-1) inhibit apoptosis in cancer cells?
Conclusion
The study found that PAI-1 inhibits apoptosis in cancer cells, which may explain its association with poor prognosis in tumors.
Supporting Evidence
- PAI-1 was found to inhibit apoptosis in both cancer and non-cancer cells.
- The study used specific drugs to induce apoptosis in the tested cell lines.
Takeaway
This study shows that a protein called PAI-1 can stop cells from dying, which might help tumors grow bigger.
Methodology
The study used human prostate cancer and leukemia cell lines to test the effects of PAI-1 on apoptosis induced by specific drugs.
Digital Object Identifier (DOI)
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