Heat Shock Protein 90 in Lobular Neoplasia of the Breast
Author Information
Author(s): Zagouri Flora, Nonni Afrodite, Sergentanis Theodoros N, Papadimitriou Christos A, Michalopoulos Nikolaos V, Lazaris Andreas C, Patsouris Efstratios, Zografos George C
Primary Institution: Breast Unit, 1st Department of Propaedeutic Surgery, Hippokratio Hospital, University of Athens
Hypothesis
Is Hsp90 expression associated with estrogen receptor alpha and beta immunostaining in lobular neoplasia of the breast?
Conclusion
Hsp90 expression was lower in lobular neoplasia foci compared to normal tissue, suggesting it does not play a major role in lobular neoplasia pathogenesis.
Supporting Evidence
- Hsp90 immunoreactivity was mainly cytoplasmic in both normal breast and lobular neoplasia.
- The percentage of Hsp90 positive cells was similar in lobular neoplasia and normal tissue, but the intensity score was significantly lower in lobular neoplasia.
- Hsp90 Allred score was significantly lower in lobular neoplasia compared to normal adjacent tissue.
Takeaway
This study looked at a protein called Hsp90 in breast tissue that has some abnormal growth. It found that this protein was less active in the abnormal tissue than in normal tissue.
Methodology
Tissue specimens were taken from 44 patients with lobular neoplasia, and immunohistochemical assessment of Hsp90, ER-alpha, and ER-beta was performed.
Limitations
The study's findings may not reflect the status in invasive lobular carcinomas due to the focus on lobular neoplasia only.
Participant Demographics
Patients' ages ranged from 34 to 67 years, with a median age of 48.
Statistical Information
P-Value
0.029, 0.049
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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