p53FamTaG: A Database of Human p53 Family Target Genes
Author Information
Author(s): Sbisà Elisabetta, Catalano Domenico, Grillo Giorgio, Licciulli Flavio, Turi Antonio, Liuni Sabino, Pesole Graziano, De Grassi Anna, Caratozzolo Mariano Francesco, D'Erchia Anna Maria, Navarro Beatriz, Tullo Apollonia, Saccone Cecilia, Gisel Andreas
Primary Institution: Istituto di Tecnologie Biomediche-Sede di Bari, CNR
Hypothesis
The identification of genes transactivated by p53 family members is crucial to understand their specific roles in cell cycle regulation.
Conclusion
p53FamTaG is a unique resource that integrates human direct p53 family target genes and provides an efficient query system for researchers.
Supporting Evidence
- The database contains 18,110 human genes identified as potential p53 family direct target genes.
- It integrates in silico predictions with experimental microarray data.
- The database allows users to export responsive element sequences for further analysis.
Takeaway
The p53FamTaG database helps scientists find genes that are controlled by p53, p63, and p73, which are important for understanding cancer.
Methodology
The study combined a genome-wide computational search for p53 family responsive elements with microarray analysis of gene expression in stable isogenic cell lines.
Limitations
The database may not include all potential target genes due to the specificity of the search criteria and the experimental conditions used.
Digital Object Identifier (DOI)
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