Prognostic Value of D5 Protein in Colorectal Cancer
Author Information
Author(s): J.F.R. Robertson, D.L. Morris, I.O. Ellis, N.C. Armitage, J.D. Hardcastle
Primary Institution: University Hospital Nottingham, UK
Hypothesis
Does the expression of D5 protein in primary colorectal cancers have prognostic significance?
Conclusion
The study found no correlation between D5 immunoreactivity and recurrence or overall survival in colorectal cancer patients.
Supporting Evidence
- 57% of primary colorectal tumors showed positive staining for D5.
- Patients with D5 positive tumors had a significantly decreased survival time.
- Tamoxifen therapy did not affect survival in patients with D5 negative tumors.
Takeaway
This study looked at a protein called D5 in colorectal cancer to see if it could help predict how patients would do, but it didn't find any useful information.
Methodology
The study used immunohistology to assess D5 expression in colorectal cancer tissues and analyzed survival and recurrence data.
Limitations
The study had only an 80% chance of detecting a significant difference in survival, which may limit its findings.
Participant Demographics
36 women and 32 men with colorectal carcinoma.
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