Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functional molecular study
2006
Movement and Invasion of Lung Cancer Cells
publication
Evidence: moderate
Author Information
Author(s): Fok Sandra YY, Rubin Jeffrey S, Pixley Fiona, Condeelis John, Braet Filip, Soon Lilian L
Primary Institution: University of Sydney
Hypothesis
Heterogeneous cancer cells exhibit variable motility responses such as chemokinesis and chemotaxis that can be characterized molecularly.
Conclusion
Cancer cells that are efficient in both chemokinesis and chemotaxis demonstrate high invasion levels.
Supporting Evidence
- KINE cells moved faster but less directionally than the unselected control population.
- KINE cells were significantly more invasive compared to CON cells.
- Gene array studies showed the downregulation of a gene called ROM in highly chemokinetic KINE compared to mainly chemotactic CON cells.
Takeaway
Some lung cancer cells can move quickly and invade more than others, which helps them spread in the body.
Methodology
The study involved isolating a subpopulation of lung cancer cells and comparing their motility and invasiveness using Boyden chambers and time-lapse microscopy.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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