Effect of Vitamin E on Bone Growth in Rabbits
Author Information
Author(s): Kurklu Mustafa, Yildiz Cemil, Kose Ozkan, Yurttas Yuksel, Karacalioglu Ozgur, Serdar Muhittin, Deveci Salih
Primary Institution: Gulhane Military Medical Academy, Ankara, Turkey
Hypothesis
Alpha-tocopherol may have favorable effects on the quality of new bone formation during distraction osteogenesis and shorten the time required for consolidation.
Conclusion
Alpha-tocopherol has beneficial effects on new bone formation during distraction osteogenesis.
Supporting Evidence
- Radiologic scores were higher in the experimental group at the 30th and 40th days.
- Osteoblastic activity was significantly higher in the experimental group at the 20th day.
- Serum total antioxidant capacity values were significantly higher in the experimental group at the 30th day.
- Histopathologic examination revealed significantly higher scores in the experimental group.
Takeaway
This study found that giving rabbits vitamin E helped their bones heal better when they were being stretched to grow new bone.
Methodology
30 New Zealand white rabbits were divided into experimental and control groups, with the experimental group receiving alpha-tocopherol for 30 days while undergoing distraction osteogenesis.
Limitations
The study was conducted on rabbits, and further clinical studies are necessary to confirm the effects in humans.
Participant Demographics
Adult New Zealand white rabbits, mean weight 1,800 g.
Statistical Information
P-Value
0.000
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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