Effects of General vs. Spinal Anaesthesia on Stress Response in Haemorrhoidectomy
Author Information
Author(s): Unase Buyukkocak, Caglayan Osman, Daphan Cagatay, Aydinuraz Kuzey, Saygun Oral, Kaya Tahsin, Agalar Fatih
Primary Institution: Kirikkale University
Hypothesis
Does the type of anaesthesia (general vs. spinal) affect the perioperative stress response in patients undergoing haemorrhoidectomy?
Conclusion
There was no significant difference in the stress response between general and spinal anaesthesia in patients undergoing haemorrhoidectomy, except for a notable increase in leptin levels in the spinal anaesthesia group.
Supporting Evidence
- IL-6 and CRP levels increased significantly in all patients after surgery.
- Leptin levels significantly increased in patients undergoing spinal anaesthesia.
- TNF-α and cortisol levels did not change significantly after surgery.
Takeaway
The type of anaesthesia used during surgery doesn't really change how the body reacts to stress, except for one hormone that went up more with spinal anaesthesia.
Methodology
Patients were assigned to general or spinal anaesthesia groups, and blood samples were taken before and after surgery to measure stress response markers.
Limitations
The study had a small sample size and was limited to a specific type of surgery.
Participant Demographics
Patients included 7 in each anaesthesia group, with a mix of male and female participants and a median age of 49 for general anaesthesia and 34 for spinal anaesthesia.
Statistical Information
P-Value
P = .018
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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