Authors' Response to Hogan Correspondence
2006
Are Nonhuman Primates Good Models for SARS?
publication
Author Information
Author(s): Haagmans Bart L, Osterhaus Albert D. M. E
Primary Institution: Erasmus Medical Center
Hypothesis
Are nonhuman primates effective models for studying SARS?
Conclusion
Nonhuman primates, particularly macaques, may provide important insights into the pathogenesis of SARS, but their clinical outcomes may not fully replicate severe SARS in humans.
Supporting Evidence
- SARS-CoV replicates in a wide range of animal species, but the clinical outcomes vary.
- Macaques show similar infection patterns to humans but may not develop severe disease.
- Different strains of SARS-CoV may affect the severity of the disease in macaques.
Takeaway
This study looks at whether monkeys can help us understand SARS. They can, but they don't always get as sick as people do.
Limitations
The clinical signs in macaques may not fully represent severe SARS in humans, limiting their utility as a model.
Digital Object Identifier (DOI)
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