Group A Streptococcus Virulence Factors in North India
Author Information
Author(s): Dhanda V., Vohra H., Kumar R.
Primary Institution: Postgraduate Institute of Medical Education & Research, Chandigarh, India
Hypothesis
What are the virulence factors of Group A Streptococcus isolated from children with pharyngitis in North India?
Conclusion
Group A Streptococcus isolates from children in North India have highly virulent antigens and show significant diversity in emm types.
Supporting Evidence
- Twenty emm types and six sequence types were identified among the isolates.
- The spe B gene was significantly more common in opacity factor negative isolates.
- Isolates associated with severe infections showed a higher frequency of virulence factors.
Takeaway
This study looked at germs that cause throat infections in kids and found that some of them are really strong and can make people very sick.
Methodology
Fifty GAS isolates were cultured from children aged 5-15 years with varying severity of pharyngitis and characterized for virulence factors by PCR.
Participant Demographics
Children aged 5-15 years from North India.
Statistical Information
P-Value
0.0007
Statistical Significance
p<0.05
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