Ki-67 and Prognosis in Synovial Sarcoma
Author Information
Author(s): Skytting B T, Bauer H C, Perfekt R, Nilsson G, Larsson O
Primary Institution: Department of Orthopedics, Stockholm Soder Hospital
Hypothesis
The study investigates the prognostic importance of MIB-1 index, p53 expression, and tumor size in synovial sarcoma.
Conclusion
The study found that metastatic disease in synovial sarcoma is closely related to the MIB-1 index and tumor size.
Supporting Evidence
- The study identified two metastatic risk factors: increasing tumor size and MIB-1 >9%.
- Patients with tumor size ≤5 cm and MIB-1 <10% had a 5-year metastasis-free survival rate of 0.83.
- Patients with tumor size >5 cm and MIB-1 ≥10% had a 5-year metastasis-free survival rate of 0.31.
Takeaway
This study looked at patients with a type of cancer called synovial sarcoma and found that certain test results can help doctors know who might get worse and need more treatment.
Methodology
The study analyzed formalin-fixed paraffin-embedded material from patients and performed multivariate analysis.
Participant Demographics
Patients with primary synovial sarcoma located in the extremities or trunk wall.
Statistical Information
Confidence Interval
95% CI 0.64–0.92 for good prognosis; 95% CI 0.11–0.53 for poor prognosis.
Digital Object Identifier (DOI)
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