Metazoan Scc4 Homologs Link Sister Chromatid Cohesion to Cell and Axon Migration Guidance
2006
Ancient Protein Partners and Their New Roles in Animals
publication
Evidence: moderate
Author Information
Author(s): Vlad Seitan, Tom Strachan, Richard Robinson
Hypothesis
Do ancient proteins take on new roles in multicellular organisms?
Conclusion
The study shows that ancient proteins involved in chromosome cohesion also play roles in guiding multicellular development.
Supporting Evidence
- The proteins Scc2 and Scc4 help chromosomes divide and have counterparts in other organisms.
- RNA interference showed that reducing MAU-2 levels led to premature separation of sister chromatids.
- MAU-2 is involved in guiding cell movements and growth of axons during development.
Takeaway
Some old proteins in our bodies help with new jobs, like guiding how cells grow and move, not just helping chromosomes divide.
Methodology
The authors used RNA interference and antisense techniques to study the roles of MAU-2 in various organisms.
Digital Object Identifier (DOI)
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