Study of Relatedness Between Two Lantibiotics
Author Information
Author(s): Eileen B. O'Connor, Paul D. Cotter, Paula O'Connor, Orla O'Sullivan, John R. Tagg, R. Paul Ross, Colin Hill
Primary Institution: Moorepark Food Research Centre, Teagasc, Fermoy, Co. Cork, Ireland
Hypothesis
What is the significance of the relatedness between the two-component lantibiotics lacticin 3147 and staphylococcin C55?
Conclusion
Despite their similarities, lacticin 3147 and staphylococcin C55 exhibit unique features that are specific to each system.
Supporting Evidence
- Lacticin 3147 and staphylococcin C55 are closely related two-component lantibiotics.
- The hybrid peptide pairs showed activities in the single nanomolar range.
- The lacticin LtnA1 post-translational machinery can produce functionally active C55α.
Takeaway
This study shows that two similar bacteria can work together in a special way, but they also have their own unique traits.
Methodology
The study involved bioinformatic analysis, genetic replacement studies, and assays to determine the inhibitory activity of the peptides.
Digital Object Identifier (DOI)
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