Effects of Soy Isoflavones on Appetite Hormones in Postmenopausal Women
Author Information
Author(s): Martin O. Weickert, Manja Reimann, Bärbel Otto, Wendy L. Hall, Katherina Vafeiadou, Jesper Hallund, Marika Ferrari, Duncan Talbot, Francesco Branca, Susanne Bügel, Christine M. Williams, Hans-Joachim Zunft, Corinna Koebnick
Primary Institution: German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
Hypothesis
Isoflavones may influence PYY and ghrelin, and thus energy intake and body weight.
Conclusion
Soy isoflavone supplementation did not significantly reduce energy intake or body weight, despite an increase in plasma PYY levels.
Supporting Evidence
- Isoflavone treatment increased plasma PYY concentrations significantly.
- Body weight increased in both treatment periods with no significant difference between treatments.
- Ghrelin levels were unaffected by isoflavone treatment.
Takeaway
Eating soy isoflavones didn't help women lose weight or eat less, but it did increase a hormone that makes you feel full.
Methodology
A randomized, double-blind, placebo-controlled, cross-over trial with 34 healthy postmenopausal women consuming isoflavone-enriched and control cereal bars for 8 weeks each.
Limitations
The study duration may have been too short to detect relevant differences in body weight.
Participant Demographics
Healthy postmenopausal women, average age 59 years, BMI 24.7 kg/m2.
Statistical Information
P-Value
P = 0.010 for treatment differences in PYY levels.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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