ACE Genotype and Lung Problems from Mustard Gas Exposure
Author Information
Author(s): Hosseini-khalili Ali Reza, Thompson Julian, Kehoe Anthony, Hopkinson Nicholas S, Khoshbaten A, Soroush Mohammad Reza, Humphries Steve E, Montgomery Hugh, Ghanei Mostafa
Primary Institution: UCL Institute for Human Health and Performance
Hypothesis
The ACE genotype might influence the severity of late respiratory complications of mustard gas exposure.
Conclusion
The ACE D allele is associated with higher FEV1 % predicted when assessed 18 years after high exposure to mustard gas.
Supporting Evidence
- ACE genotype was determined in 207 subjects.
- The ACE DD genotype was overrepresented in the better spirometry group.
- Increasing age at the time of exposure was associated with reduced FEV1 % predicted.
Takeaway
People who were exposed to mustard gas and have a specific gene type (D allele) tend to breathe better many years later.
Methodology
208 Kurdish patients underwent clinical examination, spirometric evaluation, and ACE Insertion/Deletion genotyping.
Limitations
The study is limited by its small sample size and the need for further research with greater numbers and phenotypic detail.
Participant Demographics
All subjects were Kurdish civilians with high-level mustard gas exposure.
Statistical Information
P-Value
0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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