Plasma Factors Affect Kidney Function in Septic Burns Patients
Author Information
Author(s): Mariano Filippo, Cantaluppi Vincenzo, Stella Maurizio, Romanazzi Giuseppe Mauriello, Assenzio Barbara, Cairo Monica, Biancone Luigi, Triolo Giorgio, Ranieri V Marco, Camussi Giovanni
Primary Institution: Dipartimento di Area Medica, Unita' di Nefrologia e Dialisi, Ospedale CTO, Torino, Italy
Hypothesis
Plasma in septic burns patients induces apoptosis and functional alterations in tubular cells and podocytes, contributing to proteinuria and renal dysfunction.
Conclusion
Plasma from burns patients with sepsis-associated acute renal failure contains factors that negatively impact kidney function and contribute to proteinuria.
Supporting Evidence
- Septic burns patients with acute renal failure showed significant proteinuria.
- Proteinuria correlated with systemic inflammation and renal function impairment.
- Plasma from septic burns patients induced apoptosis in kidney cells.
- Plasma-induced apoptosis correlated with the extent of proteinuria.
- Plasma altered the expression of key proteins involved in kidney function.
Takeaway
When people get severe burns and then get an infection, their blood can harm their kidneys, making them leak proteins. This is bad for their health.
Methodology
The study involved 19 severe burns patients with septic shock and acute renal failure, correlating proteinuria with systemic inflammation and renal function, and evaluating the effects of plasma on cultured kidney cells.
Potential Biases
Potential bias due to the small sample size and specific patient demographics.
Limitations
The study was limited to a specific patient population and may not generalize to all septic patients.
Participant Demographics
19 patients with severe burns and septic shock, mean age 50.4 years, 36.8% female.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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