Causes and Consequences of Cerebral Small Vessel Disease: The RUN DMC Study
Author Information
Author(s): van Norden Anouk GW, de Laat Karlijn F, Gons Rob AR, van Uden Inge WM, van Dijk Ewoud J, van Oudheusden Lucas JB, Esselink Rianne AJ, Bloem Bastiaan R, van Engelen Baziel GM, Zwarts Machiel J, Tendolkar Indira, Olde-Rikkert Marcel G, van der Vlugt Maureen J, Zwiers Marcel P, Norris David G, de Leeuw Frank-Erik
Primary Institution: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre
Hypothesis
The study investigates the relationship between cerebral small vessel disease (SVD) and cognitive and motor decline in elderly individuals.
Conclusion
The RUN DMC study aims to uncover the causes and consequences of changes in white matter integrity in elderly individuals with cerebral SVD using advanced imaging techniques.
Supporting Evidence
- Cerebral small vessel disease is linked to cognitive and motor impairments.
- Diffusion tensor imaging can provide insights into white matter integrity.
- The study aims to identify risk factors for cognitive decline in elderly individuals.
Takeaway
This study looks at how small blood vessel problems in the brain can affect older people's thinking and movement skills.
Methodology
A prospective cohort study involving 503 non-demented elderly participants aged 50-85 with cerebral SVD, using various assessments including MRI and cognitive tests.
Limitations
The study may face challenges in participant retention over the follow-up period and the generalizability of findings due to its single-center design.
Participant Demographics
Elderly individuals aged 50-85 years with cerebral small vessel disease.
Digital Object Identifier (DOI)
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