Cell Adhesion Molecules and Mortality in Kidney Transplant Recipients
Author Information
Author(s): Grainne M Connolly, Ronan Cunningham, Peter T McNamee, Ian S Young, Alexander P Maxwell
Primary Institution: Queen's University Belfast
Hypothesis
Cellular adhesion molecules (CAMs) would predict risk of death in patients with a renal transplant.
Conclusion
The study found that elevated levels of CAMs, particularly VCAM, are significant independent predictors of mortality in renal transplant recipients.
Supporting Evidence
- Higher VCAM and ICAM levels were associated with increased mortality.
- Patients with VCAM or ICAM in the lowest third had better survival rates.
- The study included a large cohort of renal transplant recipients.
Takeaway
This study shows that certain proteins in the blood can help predict if kidney transplant patients will live longer or not.
Methodology
The study followed 378 renal transplant recipients over a median of 2441 days, measuring levels of VCAM and ICAM and collecting mortality data.
Potential Biases
The study may not be generalizable to other populations due to its specific demographic.
Limitations
The study was conducted in a single ethnic group and did not record other co-morbidities that could impact mortality.
Participant Demographics
All participants were white, with 64% male, 19% smokers, and 14% having diabetes.
Statistical Information
P-Value
p = 0.030 for VCAM, p = 0.037 for ICAM
Confidence Interval
CI for VCAM: 1.21, 4.81; CI for ICAM: 1.22, 4.70
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website