Using MRI to Detect High Pressure in the Brain
Author Information
Author(s): Geeraerts Thomas, Newcombe Virginia FJ, Coles Jonathan P, Abate Maria Giulia, Perkes Iain E, Hutchinson Peter JA, Outtrim Jo G, Chatfield Dot A, Menon David K
Primary Institution: University of Cambridge
Hypothesis
The study aims to assess the relationship between optic nerve sheath diameter (ONSD) measured by MRI and intracranial pressure (ICP).
Conclusion
ONSD measurement using MRI can provide a reliable estimate of the likelihood of significant intracranial hypertension.
Supporting Evidence
- ONSD was significantly greater in TBI patients with raised ICP than in those with normal ICP or healthy volunteers.
- A strong linear relationship was found between ONSD and ICP.
- The best cut-off value for detecting raised ICP was identified as 5.82 mm.
Takeaway
Doctors can use MRI to measure the optic nerve sheath to see if there is too much pressure in the brain, which can help them treat patients better.
Methodology
A retrospective analysis of MRI images from 38 TBI patients and 36 healthy volunteers was conducted to measure ONSD and compare it with ICP.
Potential Biases
Differences in body weight between TBI patients and healthy volunteers could introduce bias.
Limitations
MRI access is limited, and the study used relatively thick slices which may affect measurement precision.
Participant Demographics
38 TBI patients (average age 35, 80% male) and 36 healthy volunteers (average age 32, 75% male).
Statistical Information
P-Value
<0.0001
Confidence Interval
95% CI = 0.86 to 1.01
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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