Improving Flutamide Delivery with Self-Nanoemulsifying Systems
Author Information
Author(s): Jeevana Jyothi B, Sreelakshmi K
Primary Institution: Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Viswavidyalayam
Hypothesis
Can self-nanoemulsifying drug delivery systems enhance the dissolution rate of flutamide?
Conclusion
The study successfully developed a self-nanoemulsifying drug delivery system for flutamide that significantly increased its solubility and dissolution rate.
Supporting Evidence
- The optimized SNEDDS formulation showed a mean droplet size of 148.7 nm.
- The dissolution rate of flutamide from SNEDDS was significantly higher than that of the pure drug.
- The formulation contained 8.04% flutamide, 24.12% sesame oil, 53.38% Tween 20, and 14.46% PEG 400.
Takeaway
This study found a way to make a medicine called flutamide dissolve better in the body, which can help it work better.
Methodology
The study involved preparing various formulations of flutamide using sesame oil, Tween 20, and PEG 400, followed by characterization of their solubility, particle size, and dissolution rates.
Digital Object Identifier (DOI)
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