Trends in HIV Drug Resistance in Portugal
Author Information
Author(s): Jurgen Vercauteren, Koen Deforche, Kristof Theys, Michiel Debruyne, Luis Miguel Duque, Susana Peres, Ana Patricia Carvalho, Kamal Mansinho, Anne-Mieke Vandamme, Ricardo Camacho
Primary Institution: Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
Hypothesis
Is the incidence of multidrug and full class resistance in HIV-1 infected patients decreasing over time in Portugal?
Conclusion
The incidence of multidrug and full class resistance is decreasing over time in Portugal, except for NNRTI full class resistance which showed an initial rise but subsequently declined.
Supporting Evidence
- From July 2001 to July 2006, there was a significant decreasing trend of multidrug resistance.
- For every consecutive year, the odds of having a new multidrug-resistant case decreased by 20%.
- NRTI- and PI-FCR showed a decline over time.
- NNRTI-FCR exhibited a parabolic trend with a maximum incidence in 2003-2004.
Takeaway
The number of people with drug-resistant HIV is getting smaller in Portugal, which is good news for treatment.
Methodology
Analysis of 3394 viral isolates genotyped from 2000 to 2006 using the Rega 6.4.1 interpretation system.
Potential Biases
Potential bias due to the time elapsed since therapy initiation and the accuracy of genotyping.
Limitations
The study may be affected by left censoring bias and the accuracy of therapy initiation dates.
Participant Demographics
Patients from 22 hospitals across Portugal, including the Madeira Archipelago.
Statistical Information
P-Value
0.003
Confidence Interval
95%-CI: 0.69 – 0.93
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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