Inhibition of Citrinin Production in Penicillium citrinum Cultures by Neem [Azadirachta indica A. Juss (Meliaceae)]
2008
Inhibition of Citrinin Production in Penicillium citrinum Cultures by Neem
Sample size: 3
publication
Evidence: moderate
Author Information
Author(s): Simone Aparecida Mossini, Carlos Kemmelmeier
Primary Institution: State University of Maringá
Hypothesis
Can neem leaf extract inhibit citrinin production in Penicillium citrinum?
Conclusion
Neem leaf extract significantly inhibits citrinin production in Penicillium citrinum without affecting fungal growth.
Supporting Evidence
- Citrinin production was inhibited by approximately 80% with 3.12 mg/mL of neem extract.
- High-performance liquid chromatography confirmed the results of spectrophotometric analysis.
- Fungal growth was not inhibited by neem extract, indicating selective inhibition of toxin production.
Takeaway
Neem leaves can help stop a harmful substance made by certain fungi without making the fungi grow slower.
Methodology
The study used different concentrations of neem leaf extract in cultures of three isolates of Penicillium citrinum to assess growth and citrinin production.
Limitations
The study did not explore the long-term effects of neem extract on fungal growth and citrinin production.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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