The Role of Extracellular Vesicles-Delivered miRNAs in Brain-Periphery Communication
Author Information
Author(s): D’Amico Giuseppa, Carista Adelaide, Manna Olga Maria, Paladino Letizia, Picone Domiziana, Sarullo Silvia, Sausa Martina, Cappello Francesco, Vitale Alessandra Maria, Caruso Bavisotto Celeste
Primary Institution: University of Palermo
Hypothesis
Understanding the role of EVs-delivered miRNAs in brain-periphery communication could provide insights for treating neurological and systemic diseases.
Conclusion
The study highlights the potential of EVs-delivered miRNAs as biomarkers and therapeutic targets for neurological and systemic diseases.
Supporting Evidence
- Extracellular vesicles can cross the blood-brain barrier, facilitating communication between the brain and peripheral organs.
- miRNAs delivered by extracellular vesicles can modulate gene expression in recipient cells.
- Altered expression of peripheral tissue-specific miRNAs may affect central nervous system function.
- Understanding EVs-delivered miRNAs could lead to new therapeutic strategies for neurological diseases.
- Research indicates that EV-based therapies are safe and well tolerated in humans.
Takeaway
This study shows that tiny particles called extracellular vesicles can carry important molecules between the brain and other body parts, which might help us understand and treat diseases.
Methodology
The review synthesizes existing literature on the communication between the brain and peripheral organs mediated by EVs and miRNAs.
Limitations
The mechanisms of EVs and miRNAs in brain-periphery communication are not fully understood, and much evidence is indirect.
Digital Object Identifier (DOI)
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