Increased expression of the RIα subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer
1999
RIα Subunit and Ovarian Cancer Stages
Sample size: 40
publication
Evidence: moderate
Author Information
Author(s): McDaid H M, Cairns M T, Atkinson R J, McAleer S, Harkin D P, Gilmore P, Johnston P G
Primary Institution: The Queen's University of Belfast
Hypothesis
The study aims to assess the prognostic importance of RIα expression in patients with ovarian cancer.
Conclusion
High RIα mRNA expression is associated with advanced stage ovarian cancer.
Supporting Evidence
- RIα mRNA expression was significantly associated with tumour stage.
- High RIα mRNA expression was linked to advanced stage disease.
- No significant difference in RIα mRNA expression was found between different ovarian histological subtypes.
Takeaway
This study found that higher levels of a specific protein in ovarian cancer cells are linked to more advanced cancer stages.
Methodology
The study evaluated RIα expression using quantitative reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis.
Statistical Information
P-Value
P=0.0036
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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