Cancer Mortality in Relatives of Young Breast Cancer Patients
Author Information
Author(s): K.E. Anderson, D.F. Easton, F.E. Matthews, J. Peto
Primary Institution: Institute of Cancer Research
Hypothesis
Is there an increased risk of cancer mortality in first-degree relatives of young breast cancer patients?
Conclusion
The study found significantly increased breast cancer mortality in first-degree relatives of young breast cancer patients, particularly below age 60.
Supporting Evidence
- Breast cancer mortality was significantly elevated in relatives under age 60 with a standardized mortality ratio (SMR) of 3.4.
- Cumulative breast cancer incidence in relatives was 3.6% by age 50 and 11.6% by age 70.
- Excess mortality was also observed for cancers of reproductive sites and lung in relatives under age 60.
Takeaway
If your mom or sister had breast cancer when they were young, you might have a higher chance of getting it too.
Methodology
A retrospective cohort study tracing mothers and sisters of breast cancer patients through national health records for mortality and cancer incidence.
Potential Biases
Potential bias in tracing relatives who died young, as their details may be less accurately recalled.
Limitations
The study may have biases due to untraced relatives and reliance on reported family history.
Participant Demographics
The study focused on mothers and sisters of breast cancer patients aged under 36, primarily white women diagnosed in Britain.
Statistical Information
P-Value
p<0.05
Confidence Interval
(1.76, 3.55)
Statistical Significance
p<0.05
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