Acid regurgitation associated with persistent cough after pulmonary resection: an observational study
2006

Acid Reflux and Coughing After Lung Surgery

Sample size: 17 publication Evidence: moderate

Author Information

Author(s): Sawabata Noriyoshi, Takeda Shin-ichi, Tokunaga Toshiteru, Inoue Masayoshi, Maeda Hajime

Primary Institution: Dokkyo Medical University School of Medicine

Hypothesis

Is there a relationship between acid regurgitation and persistent cough after pulmonary resection?

Conclusion

There is a relationship between acid regurgitation and persistent cough in some patients shortly after surgery, but most did not show improvement in acid regurgitation after one year.

Supporting Evidence

  • 10 out of 10 patients in the Type A group had a symptom association probability greater than 95%.
  • 8 out of 10 patients with persistent coughing improved after treatment with medication.

Takeaway

Some people cough a lot after lung surgery because of acid coming up from their stomach, but even after treatment, many still cough a year later.

Methodology

Patients underwent 24-hour esophageal pH monitoring to assess acid regurgitation and its relationship with coughing.

Limitations

The study may have been affected by irritability from the pH monitoring procedure.

Participant Demographics

{"total":17,"coughing":13,"no_coughing":4,"age":{"median":66,"range":"36-72"},"gender":{"male":8,"female":9}}

Statistical Information

P-Value

0.03

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1745-9974-2-9

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