Comparing Two Treatments for Glaucoma
Author Information
Author(s): Zhao Jia-Liang, Ge Jian, Li Xiao-Xin, Li Yu-Min, Sheng Yao-Hua, Sun Nai-Xue, Sun Xing-Huai, Yao Ke, Zhong Zheng
Primary Institution: Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China
Hypothesis
Is the fixed combination of latanoprost and timolol as effective as the unfixed combination in reducing intraocular pressure in Chinese patients with glaucoma?
Conclusion
The fixed combination treatment is at least as effective as the unfixed combination in lowering eye pressure in patients with glaucoma.
Supporting Evidence
- Both treatments significantly lowered intraocular pressure from baseline.
- The fixed combination was well tolerated with low adverse event rates.
- Mean IOP reductions were similar in both treatment groups.
- 96% of subjects completed the study.
- Conjunctival hyperemia was the most common adverse event.
Takeaway
This study looked at two ways to treat eye pressure in people with glaucoma. Both ways worked well, but the fixed combination was just as good as the other.
Methodology
An 8-week, randomized, open-label, parallel-group study comparing the fixed combination with the unfixed combination in patients with glaucoma.
Potential Biases
The open-label design may introduce bias, although randomization was used.
Limitations
The study was open-label and had a short follow-up period.
Participant Demographics
Participants were Chinese patients aged 18 and older with primary open-angle glaucoma or ocular hypertension.
Statistical Information
P-Value
0.15
Confidence Interval
95% CI: -0.3 to 1.0
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website