Microbiota and Cardiovascular Health
Author Information
Author(s): Zeng Shengyin, Li Yaxin, Chen Bangwei, Ruan Lei, Zhang Jianguo, Zhu Shida, Zhang Cuntai, Li Tao
Primary Institution: BGI Genomics, Shenzhen, Guangdong, China; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Hypothesis
Can gut microbiota influence brachial-ankle pulse wave velocity (baPWV) and thus protect against cardiovascular disease?
Conclusion
Higher abundance of certain gut bacteria is associated with lower baPWV, which may reduce the risk of cardiovascular disease.
Supporting Evidence
- Higher abundance of Bifidobacterium adolescentis is associated with lower baPWV.
- Higher abundance of Lachnospiraceae is associated with lower baPWV.
- MR evidence suggests a causal relationship between higher abundance of Lactobacillales and higher baPWV.
- MR evidence suggests a causal relationship between higher abundance of Citrobacter and higher baPWV.
- MR evidence suggests a causal relationship between higher abundance of Ruminococcus and higher baPWV.
Takeaway
Some tiny living things in our tummy can help keep our hearts healthy by making our blood vessels less stiff.
Methodology
Two-sample bidirectional Mendelian randomization analysis was used to assess the relationship between gut microbiota and baPWV.
Participant Demographics
Participants were from the Tongji-BGI research cardiovascular health (TORCH) cohort.
Statistical Information
P-Value
1.81×10-4; 2.88×10-5; 1.72×10-3; 1.46×10-2; 1.36×10-4
Digital Object Identifier (DOI)
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