Characterization and Safety Assessment of a Novel Antioxidant Excipient from Sustainable Recovery of Grape Processing Waste Bentonite Designed to Develop a Thermosensitive Buccal Spray for Oral Cavity Wellness
2024

New Antioxidant Spray from Grape Waste

publication 10 minutes Evidence: high

Author Information

Author(s): Di Prima Giulia, Belfiore Elena, La Mantia Cecilia, Indelicato Serena, Avellone Giuseppe, De Caro Viviana

Primary Institution: University of Palermo

Hypothesis

Can polyphenols extracted from black bentonite waste be used to create a safe and effective buccal spray for oral wellness?

Conclusion

The study confirms that black bentonite is a valuable source of polyphenols, and the developed buccal spray is effective for oral care.

Supporting Evidence

  • PEG200 was identified as an effective extraction solvent for polyphenols.
  • The developed buccal spray gelled at body temperature, enhancing retention in the oral cavity.
  • In vitro tests showed no skin or eye irritation from the P extract.
  • The antioxidant properties of the extracts were confirmed through DPPH assays.
  • Polyphenols were effectively extracted from black bentonite waste, supporting sustainability efforts.

Takeaway

Researchers made a new mouth spray using leftovers from grape processing that helps keep your mouth healthy and is safe to use.

Methodology

The study involved extracting polyphenols from black bentonite using green solvents, followed by in vitro safety assessments and formulation of a buccal spray.

Potential Biases

Potential bias may arise from the use of specific extraction methods and the selection of tested polyphenols.

Limitations

The study primarily focuses on in vitro assessments, and further in vivo studies are needed to confirm the effectiveness and safety in humans.

Statistical Information

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.3390/pharmaceutics16121612

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