Surgery to Prevent Breast and Ovarian Cancer in High-Risk Women
Author Information
Author(s): Batista Larissa I, Lu Karen H, Beahm Elisabeth K, Arun Banu K, Bodurka Diane C, Meric-Bernstam Funda
Primary Institution: The University of Texas M. D. Anderson Cancer Center
Hypothesis
Is coordinated prophylactic mastectomy and bilateral salpingo-oophorectomy feasible for women with hereditary breast-ovarian cancer syndrome?
Conclusion
Coordinated prophylactic mastectomy and BSO is a feasible procedure with acceptable morbidity in selected high-risk patients.
Supporting Evidence
- Twelve high-risk women underwent coordinated PM and BSO.
- Ten patients had a history of previous breast cancer.
- At a mean follow-up of 84 months, 10 patients were cancer-free.
- No patients developed a new primary cancer.
Takeaway
This study looked at women at high risk for breast and ovarian cancer and found that doing two surgeries at once can be safe and helpful.
Methodology
The study reviewed clinical characteristics and surgical outcomes of high-risk women who underwent coordinated PM and BSO.
Potential Biases
The results may not be generalizable due to the expertise of the surgical team at a single institution.
Limitations
The study is limited by its small sample size and retrospective design from a single institution.
Participant Demographics
The mean age of participants was 43 years, with a range of 34 to 65 years; most had a history of breast cancer.
Digital Object Identifier (DOI)
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