Ascorbic Acid's Role in Cancer Cell Growth
Author Information
Author(s): Belin Sophie, Kaya Ferdinand, Duisit Ghislaine, Giacometti Sarah, Ciccolini Joseph, Fontés Michel
Primary Institution: Faculté de Médecine de la Timone, Marseille, France
Hypothesis
Can ascorbic acid inhibit the expression of genes necessary for cell cycle progression and affect tumor growth?
Conclusion
Ascorbic acid has an antiproliferative effect on cancer cells, likely due to its ability to inhibit genes involved in protein synthesis.
Supporting Evidence
- Ascorbic acid inhibited the expression of genes necessary for cell cycle progression.
- High concentrations of ascorbic acid induced S-phase arrest in cancer cells.
- In vivo studies showed reduced tumor growth in mice treated with high doses of ascorbic acid.
Takeaway
Ascorbic acid, or Vitamin C, can help stop cancer cells from growing by blocking certain genes, but it only works at high doses.
Methodology
The study used human pangenomic microarrays and in vitro assays to analyze the effects of ascorbic acid on gene expression and cell proliferation.
Potential Biases
Potential bias in the selection of cell lines and animal models used in the study.
Limitations
The study primarily focused on specific cell lines and may not generalize to all cancer types.
Participant Demographics
Nude mice were used for in vivo experiments, with a focus on tumor growth.
Statistical Information
P-Value
0.0022
Confidence Interval
95%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website