Genetic Factors Linked to Non-Hodgkin Lymphoma Risk
Author Information
Author(s): Skibola Christine F., Bracci Paige M., Halperin Eran, Nieters Alexandra, Hubbard Alan, Paynter Randi A., Skibola Danica R., Agana Luz, Becker Nikolaus, Tressler Patrick, Forrest Matthew S., Sankararaman Sriram, Conde Lucia, Holly Elizabeth A., Smith Martyn T.
Primary Institution: University of California Berkeley
Hypothesis
Are polymorphisms in the estrogen receptor 1 and vitamin C receptor gene families associated with susceptibility to lymphoma?
Conclusion
The study suggests that genetic variations in estrogen, vitamin C, and matrix metalloproteinases may play a role in the development of non-Hodgkin lymphoma.
Supporting Evidence
- Sixteen SNPs in eight pathways were associated with NHL after correction for multiple testing.
- Four ESR1 SNPs were associated with reduced risk of follicular lymphoma.
- Novel associations with common variants in estrogen receptor 1 and vitamin C receptor genes were observed.
Takeaway
Some genes related to estrogen and vitamin C might make people more likely to get a type of cancer called lymphoma.
Methodology
The study examined 768 SNPs in 146 genes using a case-control design with 1,292 cases and 1,375 controls.
Potential Biases
Potential for selection bias due to the case-control design and participant demographics.
Limitations
The study was restricted to HIV-negative participants of white non-Hispanic origin, which may limit generalizability.
Participant Demographics
Participants were primarily white non-Hispanic individuals from the San Francisco Bay Area.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI = 0.23–0.77
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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