Vitamin D receptor gene polymorphisms are associated with breast cancer risk in a UK Caucasian population
2001
Vitamin D Gene Variants and Breast Cancer Risk
Sample size: 422
publication
Evidence: moderate
Author Information
Author(s): Bretherton-Watt D, Given-Wilson R, Mansi J L, Thomas V, Carter N, Colston K W
Primary Institution: St George’s Hospital Medical School
Hypothesis
Are polymorphisms in the vitamin D receptor gene associated with breast cancer risk in a UK Caucasian population?
Conclusion
The study found that certain genetic variants in the vitamin D receptor gene are linked to an increased risk of breast cancer.
Supporting Evidence
- The study recruited 241 women following a negative screening mammogram and 181 women with known breast cancer.
- The VDR polymorphism BsmI was significantly associated with increased breast cancer risk.
- The odds ratio for the bb vs BB genotype was 2.32.
Takeaway
This study looked at how some changes in a gene related to vitamin D might make people more likely to get breast cancer.
Methodology
The study recruited women with and without breast cancer to investigate the association of VDR gene polymorphisms with breast cancer risk.
Participant Demographics
UK Caucasian women
Statistical Information
Confidence Interval
95% CI, 1.23–4.39
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website