Model-based Monitoring of Heart Issues in Pigs
Author Information
Author(s): Revie JA, Stevenson DJ, Chase JG, Hann CE, Lambermont BC, Ghuysen A, Kolh P, Shaw GM, Desaive T
Hypothesis
Can a subject-specific cardiovascular system model accurately diagnose and track changes in acute pulmonary embolism using available measurements?
Conclusion
The study found that subject-specific cardiovascular models can effectively diagnose and monitor heart changes due to acute pulmonary embolism in pigs.
Supporting Evidence
- Modelled mean ventricular volumes and maximum ventricular pressures matched measured values with median absolute errors of 4.3% and 4.4%.
- An increase in pulmonary vascular resistance was identified in all pigs and related well to experimental values (R = 0.68).
- Detrimental changes in reflex responses were noticed in two pigs that died during the trial.
- Increases in the ratio of the modelled right to left ventricular end diastolic volumes compared well with the clinically measured index (R = 0.88).
Takeaway
Researchers used pigs to test a new way to check heart problems, and it worked well to see how the heart changed when there was a blockage.
Methodology
Measurements were taken from five pig trials where blood clots were inserted to simulate pulmonary embolism, and a cardiovascular model was fitted to the data.
Limitations
The study was conducted on a small sample size of pigs, which may limit the generalizability of the results to humans.
Participant Demographics
Porcine model used in trials.
Digital Object Identifier (DOI)
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