Study of Extranodal NK/T-cell Lymphoma in Thailand
Author Information
Author(s): Pongpruttipan Tawatchai, Kummalue Tanawan, Bedavanija Anan, Khuhapinant Archrob, Ohshima Koichi, Arakawa Fumiko, Niino Daisuke, Sukpanichnant Sanya
Primary Institution: Mahidol University, Thailand
Hypothesis
The study aims to characterize immunophenotypic profiles and the distribution of EBV subtype and LMP-1 gene deletion in ENKTL.
Conclusion
The study found that TIA-1 and EBER are the most sensitive markers for ENKTL, and loss of perforin expression is associated with poorer survival outcomes.
Supporting Evidence
- ENKTL accounted for 31% of T- and NK-cell lymphomas in Thailand.
- All tested cases were negative for CD1a, CD10, CD15, CD57, CD23, CD34, CD79a, CD117, CD138, TdT, cyclin D1, PAX5, and BOB.1.
- 15 of 22 cases had EBV subtype A.
- 87% of tested cases had LMP-1 gene deletion.
Takeaway
This study looked at a type of cancer called ENKTL and found that certain markers can help identify it, and not having a specific protein can mean a person might not live as long.
Methodology
The study used tissue microarray, immunohistochemical studies, and EBV encoded RNA in situ hybridization.
Limitations
The study had a small sample size and was limited to cases diagnosed at a single institution.
Participant Demographics
{"age_range":"15-74 years","median_age":42,"male_female_ratio":"2.9"}
Statistical Information
P-Value
0.008
Statistical Significance
p = 0.008
Digital Object Identifier (DOI)
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