Protein Citrullination in Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases
2024
Protein Citrullination in ALS and Other Neurodegenerative Diseases
publication
Evidence: moderate
Author Information
Author(s): Yusuf Issa O., Camille Webb, Thompson Paul R., Xu Zuoshang
Primary Institution: University of Massachusetts Chan Medical School
Hypothesis
How does protein citrullination impact neurodegeneration?
Conclusion
Protein citrullination is increased in neurodegenerative diseases and may contribute to disease progression.
Supporting Evidence
- Protein citrullination is a hallmark of neurodegenerative diseases.
- In ALS, protein citrullination is increased in astrocytes and associated with neurodegeneration.
- Decreased protein citrullination in neurons may signal compromised neuronal function.
- Protein citrullination may serve as a potential biomarker for ALS.
Takeaway
This study looks at how a process called protein citrullination might be involved in diseases like ALS, which makes people lose control of their muscles.
Methodology
The review summarizes current understanding and investigative methods related to protein citrullination in neurodegenerative diseases.
Limitations
The exact role of protein citrullination in neurodegeneration is still not fully understood.
Digital Object Identifier (DOI)
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