Diversity of Type 1 Lantibiotic Gene Clusters in Bacteria
Author Information
Author(s): Marsh Alan J, O'Sullivan Orla, Ross R Paul, Cotter Paul D, Hill Colin
Primary Institution: Teagasc, Moorepark Food Research Centre, Fermoy, Cork, Ireland
Hypothesis
Can in silico analysis identify novel lantibiotic gene clusters in genome sequenced bacteria?
Conclusion
The study identified 49 novel type 1 lantibiotic gene clusters, suggesting these antimicrobials are more widespread than previously thought.
Supporting Evidence
- 49 novel type 1 lantibiotic clusters were identified.
- Clusters were found in bacteria not previously associated with lantibiotic production.
- Type 1 lantibiotics have potential as preservatives and therapeutic agents.
Takeaway
Scientists found many new types of natural antibiotics in bacteria that were not known to make them before, which could help in fighting infections.
Methodology
An in silico approach was used to identify lantibiotic-encoding gene clusters by screening genomic databases for homologous genes.
Limitations
The identification of gene clusters does not guarantee the production of active lantibiotics.
Digital Object Identifier (DOI)
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