c-erbB-2 Protein Expression in Papillary Thyroid Carcinomas
Author Information
Author(s): D.R.F. Haugen, L.A. Akslen, J.E. Varhaug, J.R. Lillehaug
Primary Institution: University of Bergen
Hypothesis
The study investigates the expression of c-erbB-2 protein in papillary thyroid carcinomas compared to non-neoplastic tissue.
Conclusion
c-erbB-2 protein is expressed in papillary thyroid carcinomas, which is not seen in non-neoplastic thyroid tissue.
Supporting Evidence
- c-erbB-2 immunoreactivity was detected in 12 out of 17 papillary carcinomas.
- No c-erbB-2 protein immunostaining was seen in non-neoplastic tissue.
- c-erbB-2 mRNA was detectable in all samples, with higher levels in papillary carcinomas compared to non-neoplastic tissue.
Takeaway
This study found that a specific protein, c-erbB-2, is present in certain thyroid cancers but not in normal thyroid tissue.
Methodology
The study used immunohistochemistry on frozen thyroid tissue samples and RNA slot blot hybridization for analysis.
Limitations
The study's findings may be limited by the small number of certain cancer types included.
Participant Demographics
Patients included 42 individuals who underwent thyroidectomy, with various thyroid conditions.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Want to read the original?
Access the complete publication on the publisher's website