RP105's Role in Collagen-Induced Arthritis
Author Information
Author(s): Tada Yoshifumi, Koarada Syuichi, Morito Fumitaka, Mitamura Mio, Inoue Hisako, Suematsu Rie, Ohta Akihide, Miyake Kensuke, Nagasawa Kohei
Primary Institution: Saga Medical School
Hypothesis
RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis.
Conclusion
RP105 regulates the antigen-presenting cell function and Treg development, which suppresses the development of collagen-induced arthritis.
Supporting Evidence
- RP105-deficient mice showed accelerated onset of arthritis and increased severity.
- Interferon-gamma and tumor necrosis factor-alpha production by spleen cells from RP105-deficient mice was increased compared to wild-type mice.
- RP105-deficient mice had more severe arthritis induced by collagen with incomplete Freund's adjuvant.
Takeaway
This study found that mice without RP105 got arthritis faster and more severely, showing that RP105 helps control the immune response.
Methodology
Collagen-induced arthritis was induced in RP105-deficient DBA/1 mice, and the incidence and severity of arthritis were analyzed along with cytokine production.
Limitations
The study did not determine the precise role of TLRs due to potential contamination of LPS with TLR2 ligands.
Participant Demographics
Mice were 12 to 16 weeks old, with both male and female subjects used.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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