Association of Variants in IL-1RN (rs2234663) and IL-1β (rs1143627, rs16944) and Interleukin-1β Levels with Colorectal Cancer: Experimental Study and In Silico Analysis

2024

Genetic Variants in IL-1RN and IL-1β Linked to Colorectal Cancer

Sample size: 486 publication 10 minutes Evidence: moderate

Author Information

Author(s): Gallegos-Arreola Martha Patricia, Garibaldi-Ríos Asbiel Felipe, Gutiérrez-Hurtado Itzae Adonaí, Zúñiga-González Guillermo Moisés, Figuera Luis E., Gómez-Meda Belinda Claudia, Puebla-Pérez Ana María, García-Ortiz José Elías, Delgado-Saucedo Jorge I., Castro-García Paola Beatriz, Rentería-Ramírez María de Jesús, Torres-Mendoza Blanca Miriam

Primary Institution: Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social

Hypothesis

This study analyzes the association of the IL-1RN (rs2234663) and IL-1β (rs1143627, rs16944) variants and IL-1β levels with colorectal cancer.

Conclusion

The analyzed variants are associated with colorectal cancer and may influence gene regulation by being located at critical sites of key genetic regulators.

Supporting Evidence

The A1A1 genotype and dominant pattern of the rs2234663 variant were risk factors for CRC.
The TC genotype of the rs1143627 variant was associated with increased risk.
The T allele of rs16944 was associated with increased risk, while the C allele had a protective effect.
IL-1β levels were not associated with CRC.
Elevated IL-1B and IL-1RN mRNA levels were found in CRC.

Takeaway

This study looked at how certain genes might affect the risk of getting colorectal cancer, finding that some gene variations can increase or decrease that risk.