CSF Metabolic and Proteomic Profiles in Patients Prodromal for Psychosis
Author Information
Author(s): Huang Jeffrey T.-J., Leweke F. Markus, Tsang Tsz M., Koethe Dagmar, Kranaster Laura, Gerth Christoph W., Gross Sonja, Schreiber Daniela, Ruhrmann Stephan, Schultze-Lutter Frauke, Klosterkötter Joachim, Holmes Elaine, Bahn Sabine
Primary Institution: Institute of Biotechnology, University of Cambridge
Hypothesis
Can metabolic and proteomic changes in cerebrospinal fluid (CSF) be identified in patients in the initial prodromal state of psychosis?
Conclusion
Biochemical disturbances in cerebrospinal fluid of prodromal patients may not be sufficient to predict clinical outcomes.
Supporting Evidence
- 36% of IPS patients displayed proteomic/metabolic profiles characteristic of first-onset schizophrenia.
- Only 29% of IPS patients received a diagnosis of schizophrenia after three years.
- The presence of biochemical alterations in the IPS group did not correlate with the risk to develop schizophrenia.
Takeaway
The study looked at the brain fluid of people who might get schizophrenia and found some changes, but these changes didn't help predict who would actually get sick.
Methodology
The study used 1H-NMR spectroscopy and SELDI mass spectrometry to analyze CSF from patients with initial prodromal symptoms, first-onset schizophrenia patients, and healthy volunteers.
Limitations
The study measured biochemical changes at a single time point, which may not reflect fluctuations in the prodromal phase.
Participant Demographics
{"healthy_volunteers":70,"first_onset_schizophrenia_patients":54,"ips_patients":24}
Digital Object Identifier (DOI)
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