Combined Effect of CCND1 and COMT Polymorphisms on Breast Cancer Risk
Author Information
Author(s): Onay Ummiye V, Aaltonen Kirsimari, Briollais Laurent, Knight Julia A, Pabalan Noel, Kilpivaara Outi, Andrulis Irene L, Blomqvist Carl, Nevanlinna Heli, Ozcelik Hilmi
Primary Institution: Mount Sinai Hospital, Toronto, Ontario, Canada
Hypothesis
The study investigates the independent and combined effects of CCND1 and COMT polymorphisms on breast cancer risk.
Conclusion
The study shows a stronger combined effect of CCND1 and COMT genotypes in breast cancer predisposition.
Supporting Evidence
- The high enzymatic activity genotype of CCND1 was associated with increased breast cancer risk.
- The heterozygous COMT genotype was also linked to breast cancer risk in Ontario.
- The combined analysis showed higher activity alleles of COMT and CCND1 increased breast cancer risk.
Takeaway
This study found that certain genetic variations can increase the risk of breast cancer, especially when they occur together.
Methodology
The study analyzed two independent Caucasian populations from Ontario and Finland, comparing breast cancer cases to population controls.
Potential Biases
Potential bias due to the selection of cases and controls from specific populations.
Limitations
The study may not account for all genetic and environmental factors influencing breast cancer risk.
Participant Demographics
Participants included Caucasian women aged 22-69 from Ontario and Finland, with varying family histories of breast cancer.
Statistical Information
P-Value
p=0.00013
Confidence Interval
95%CI (1.49–3.28)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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