LOXL1 Variants and Glaucoma in Japanese Patients
Author Information
Author(s): Tanito Masaki, Minami Masayoshi, Akahori Masakazu, Kaidzu Sachiko, Takai Yasuyuki, Ohira Akihiro, Iwata Takeshi
Primary Institution: Shimane University Faculty of Medicine
Hypothesis
The study evaluates the association of LOXL1 gene variants in Japanese patients with open-angle glaucoma.
Conclusion
The study found significant associations between LOXL1 SNPs and exfoliation syndrome/glaucoma in the Japanese population.
Supporting Evidence
- Three LOXL1 SNPs were significantly associated with exfoliation syndrome/glaucoma.
- The study included only patients aged 70 years or older to reduce misclassification.
- Allele T of rs1048661 and allele G of rs3825942 were found to be risk-associated in the Japanese population.
Takeaway
This study looked at how certain gene changes are linked to eye problems in older Japanese people. It found that some gene changes are more common in those with these eye issues.
Methodology
The study evaluated three LOXL1 variants in 393 Japanese patients aged 70 years or older with various eye conditions.
Limitations
The study only included patients aged 70 years or older, which may limit the generalizability of the findings.
Participant Demographics
393 unrelated Japanese subjects, aged 70 years or older.
Statistical Information
P-Value
1.69x10−23-3.00x10−45
Confidence Interval
95% CI for ORs ranged from 8.90–43.67 to 12.83–62.14.
Statistical Significance
p<0.05
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