HCV Genotype and Serum Markers Correlation
Author Information
Author(s): Ahmad Waqar, Ijaz Bushra, Javed Fouzia T, Kausar Humera, Sarwar Muhammad T, Gull Sana, Asad Sultan, Shahid Imran, Hassan Sajida
Primary Institution: University of the Punjab, Lahore, Pakistan
Hypothesis
Is there a correlation between HCV genotypes and serum markers in predicting clinical outcomes?
Conclusion
The study found significant correlations between HCV genotypes and various serum markers, particularly for genotype 4a.
Supporting Evidence
- The most prevalent genotype was 3a (73.9%) followed by 1a (10.7%), 4a (6.4%) and 3b (6.1%).
- No correlation was found between viral load and serum markers for genotype 3a.
- Significant correlation was observed between viral load and AST in genotype 3b.
- For genotype 4a, a significant inverse correlation with viral load and Hb level was found.
Takeaway
This study looked at how different types of the hepatitis C virus relate to blood test results, helping doctors predict how sick a patient might get.
Methodology
A prospective cross-sectional and observational study was conducted on 3160 serum HCV RNA positive patients.
Potential Biases
Potential biases may arise from the selection of patients and the reliance on self-reported data.
Limitations
The study was limited to a specific population in Pakistan and may not be generalizable to other regions.
Participant Demographics
The study included 3160 patients, with a median age of 37 years, comprising 48% males and 52% females.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI for AUC values ranged from 0.454 to 0.872.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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