Murine Models of Multiple Myeloma Induce Angiogenesis
Author Information
Author(s): Van Valckenborgh E, De Raeve H, Devy L, Blacher S, Munaut C, Noël A, Van Marck E, Van Riet I, Van Camp B, Vanderkerken K
Primary Institution: Free University Brussels
Hypothesis
Can murine 5T multiple myeloma models induce angiogenesis in vitro and in vivo?
Conclusion
The study demonstrates that murine 5T multiple myeloma models can induce angiogenesis, which is related to their capacity to produce vascular endothelial growth factor (VEGF).
Supporting Evidence
- The murine 5T multiple myeloma models were shown to induce angiogenesis in vitro using a rat aortic ring assay.
- Bone marrow samples from diseased mice exhibited a statistically significant increase in microvessel density compared to controls.
- 5T multiple myeloma cells produced vascular endothelial growth factor (VEGF), which is known to stimulate angiogenesis.
Takeaway
Researchers found that certain mouse models of multiple myeloma can help grow new blood vessels, which is important for understanding how this cancer develops.
Methodology
The study used rat aortic ring assays and bone marrow microvessel density assessments to evaluate angiogenesis.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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