Thyroid Hormone Receptor α2 in Nasopharyngeal Carcinoma
Author Information
Author(s): Lee J-W, Chen C-L, Juang B-T, Chen J-Y, Yang C-S, Doong S-L
Primary Institution: National Taiwan University
Hypothesis
The study investigates the expression of thyroid hormone receptor α2 in nasopharyngeal carcinoma compared to normal nasal epithelial cells.
Conclusion
The study found that TR-α2 expression is significantly higher in recurrent nasopharyngeal carcinoma compared to normal tissue.
Supporting Evidence
- TR-α2 mRNA was detected in 1 out of 24 normal biopsies.
- TR-α2 mRNA was found in 5 out of 27 primary tumors.
- TR-α2 mRNA was present in 15 out of 24 recurrent tumors.
- The positive rate of TR-α2 expression in recurrent NPC biopsies was significantly higher than in normal tissue.
Takeaway
Researchers looked at a special protein in cancer cells and found it was much more common in cancer than in normal cells.
Methodology
Differential display and RNA in situ hybridization were used to analyze gene expression.
Participant Demographics
The study included biopsies from 24 normal nasopharynx epithelium and 51 nasopharyngeal carcinoma patients.
Statistical Information
P-Value
<0.00001
Statistical Significance
p<0.00001
Digital Object Identifier (DOI)
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