Fluorescence Method for Drug Analysis
Author Information
Author(s): Khaled M. Elokely, Eldawy Mohamed A., Elkersh Mohamed A., El-Moselhy Tarek F.
Primary Institution: Tanta University
Hypothesis
Can N1-methylnicotinamide chloride be used as a fluorogenic agent for the quantitative estimation of drugs containing α-methylene sulfone/sulfonamide functional groups?
Conclusion
The proposed method is simple, accurate, and suitable for the analysis of various drugs in different sample types.
Supporting Evidence
- The method showed linearity over a wide concentration range for the drugs tested.
- Detection limits were comparable to other sophisticated chromatographic methods.
- The method demonstrated good accuracy and precision in various sample types.
Takeaway
This study created a new way to measure certain drugs using a special chemical that makes them glow, which helps in testing their amounts in different samples.
Methodology
A spectrofluorometric method was developed and validated for drug estimation using NMNCl as a fluorogenic agent.
Limitations
The method may not be applicable to all drug types and requires specific conditions for optimal results.
Digital Object Identifier (DOI)
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